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Further studies on the relationship between germline polymorphisms in EGFR and the toxicity and efficacy of EGFR inhibitors are warranted. Erlotinib is the only epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor currently approved for marketing in the United States.

The most common side effects of erlotinib include rash diarrhea.1-3 and two of these toxicities can be severe and can lead to discontinuation of treatment. A strong association, but some unexplained rashes and survival was observed in buy soma drugs Mesa patients receiving erlotinib for various epithelial cancers, including lung cancer, head and neck, ovarian and cancer3 Interestingly, the toxicity spectrum and the association between the clinical benefit and rash were observed in all classes buy soma drugs Mesa of EGFR inhibitors.

Rash and diarrhea associated with the EGFR inhibitor use buy soma drugs Mesa both show great variability. Several buy soma drugs Mesa possible explanations for this observation have been proposed, including pharmacodynamic and pharmacokinetic (PK) variability.4, 5 Identify the determinants of variability can give you a basic idea guiding the design of future clinical research in defining rational strategies for maximize benefits and minimize the clinical effects in patients treated with these agents.

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